Analisis Subtipe HIV-1 dan Faktor Penyebarannya pada Penderita HIV di RS. Yowari Kabupaten Jayapura, Papua

Mirna Widiyanti, Semuel Sandi, Holy A. Wibowo


Acquaired immunodeficiency Syndrome (AIDS) is a symptoms caused by infection with Human Immuno-deficiency Virus (HIV). There are two types of HIV genetically distinguished as HIV-1 and HIV-2 subtype. Subtypes of HIV-1 globally have different distribution in state, where geographical factors could affected to the subtype differences. Papua is one of the provinces that have high case of HIV/AIDS. High number of people with HIV/AIDS in Papua caused by new regional area expansion and mobilization of the population in province and district area. This study was aimed to identify the sub type HIV-1 and the risk factors that correlated in the transmission of HIV-1 type. The research study was performed by cross-sectional design. There were 36 HIV patient sample respondent willing to participate in research and they were sign inform consent. Subtype HIV-1 identification was performed by used Nested-PCR, sequencing, and BLAST to found subtype HIV-1. The interview method used a questionnaires to found of  the risk factors  related to subtype HIV-1. The results of research showed that HIV-1 subtype found in people with HIV in Yowari hospital is CRF01_AE subtype (31 respondent) and subtype B ( 5 respondent). Chi-squre and Fisher exact test analysis of risk factors that influence the spread of HIV-1 subtype showed a non significant results. The research study concluded sub-type HIV-1 in patients is CRF01_AE and subtype B and  there were not correlated risk factors with HIV-1 subtype.

Key words: HIV/AIDS , type HIV-1 , CRF01_AE , Sub type-B, RS Yowari.

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Ayouba, A., B. Souquieres, B. Njinku, P. Martin, M. Muller, F. Sinoussi, P. Mauclere, F. Simon, and E. Nerrienet. 2000. HIV-1 group N among HIV-1 seropositive individuals in Cameroon. JAIDS. 14: 2623–2625.

de Arellano, R., J. Benito. V. Soriano, M. Lopez, and A. Holguin. 2007. Impact of ethnicity and HIV-1 subtype on response to first-line antiretroviral therapy. AIDS Res Hum Retroviruses. 23(7): 891–894.

Dinas Kesehatan Provinsi Papua. 2012. Statistik kasus HIV/AIDS di Papua. Bidang Pemberantasan Penyakit Menular. Jayapura.

Direktorat Jenderal Pemberantasan Penyakit Menular dan Penyehatan Lingkungan (Dirjen P2PL). 2013. Statistik kasus HIV/AIDS di Indonesia. Kementerian Kesehatan RI. Jakarta.

Grant, I., N. Sacktor, and J. McArthur. 2005. HIV neurocognitive disorders. The neurology of AIDS. 2nd ed. pp: 357-370. Oxford University Press.

Kijak, G.H., G. Beyrer, and S. Tovanabutra. 2010. Socio-demographic and drug use factors associated with HIV-1 recombinants and dual infection in Northern Thai drug users: Association of risk with genetic complexity. US Army Research. US Departement of Defense. Alcohol. Paper 13.

Korber, B., E. Allen, A. Farmer, and G. Myers. 1995. Heterogenecity of HIV-1 and HIV-2. JAIDS. 9(supplA): S5-18.

Kunanusont, C., H.M. Foy. J.K. Kreiss, N.S. Resks. P. Phanupak, S. Rakhtam, C. Pau, and N.L. Young. 1995. HIV-1 subtypes and male to female transmission in Thailand. Lancet. 345: 1078–1083.

Lodish, H., A. Berk, P. Matsudaira, C. Kaiser, M. Kreiger, M.P. Scott, S.L. Zipursky, and J. Darnell. 2003. Moleculer genetic techniques and genomics. In: Molecular cell biology. 5th. Ed. pp: 372-374. W.H. freeman and Company. New York.

Los Alamos National Laboratory. 2012. HIV Circulating Recombinant Form (CRFs)[serialonline][cited2012Jul2]. Availablefrom:URL:

Mastro, T.D., C. Kunanusont. T.J. Dondero and C. Wasi. 1997. Why do HIV-1 subtypes segregate among persons with different risk behaviour in South Africa and Thailand. JAIDS. 11: 113–116.

Merati, T.P., C. Ryan, S. Turnbul, D.N. Wirawan, B. Otto, and I.M. Bakta. 2009. Subtipe HIV-1 di beberapa daerah di Indonesia dan perannya sebagai petunjuk dinamika epidemi HIV. Indonesian Journal of Biomedical Sciences. 2(2): 1–25.

Myers, G. 1994. Tenth anniversary perspectives on AIDS. HIV: between past and future. AIDS. Res. Hum. Retroviruses. 10: 1317–1324.

Peeters, M. 2001. Review: Recombinant HIV. Sequences. Their role in the global epidemic. 1994. Los Alamos. NM: HIV sequence databases.

Pianiazek, D., Y. Chunfu, and B.L. Renu. 1994. Phylogenetic analysis og gp41 envelope of HIV-1 groups M, N and O strain provide alternate region for subtypes determination. Pp: III-112-III-117. In: Human Retrovitus and AIDS : Eds: B. Korber, B. Foley, F. McCuthan, J. Mellors, B.H. Hahn, J. Sodroski, C. Kuiken. Los Alamos National Laboratory. New Mexico.

Raboni, S.M., S.M. Alameida, I. Rotta, C.E. Ribeiro, D. Rosario, R. Vidal, B. Nogueira, M. Riedel, M.G. Winhesccki, K.A. Ferreira, and R. Ellis. 2010. Molecular epidemiology of HIV-1 clades in Southern Brazil. Memt Ints Oswaldo Cruz. 105(8): 1044–1048.

Remy, G. 1993. Epidemiologic distribution of HIV-2 infection in sub sahara Africa. Med Trops. 53(4): 511–516.

Sambrook, J., and D.W. Russel. 2001. Molecular cloning. A laboratory Manual. 3rd ed. Cold spring Harbor Laboratory Press. New York.

Santoro, M.M. and C.F. Perno. 2013. HIV-1 Genetic Variability and Clinical Implications. ISRN Microbiology. Article ID 481314,20 pages. 1-11.

Srisuphanut, M., W. Sukeepaisarnchaeron, C. Kuchererand and G. Pauli. 2004. Epidemiology of HIV-1 subtypes in infected patients from Norteastern Thailand. Southeast Asian J Tropmed Public Health. 35(3): 641–646.

Wibowo, H.A., V. Setyawaty and E. Salwati. 2011. Epidemiologi molekuler genotipe HIV-1 pada ODHA di Jawa Timur dan DKI Jakarta. Bul. Penelitian Kesehatan. 39(1): 1–9.



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